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Clinical Analyzer Feed Water

Water Purification Systems for Clinical Diagnostics

​Water purity has always been important in clinical diagnostics but ongoing developmentMedica, Clinical Analyzer Feed Systemss in the approach to clinical testing and in the sophistication and range of tests available have made water purity even more critical. Poor water quality not only directly affects the tests themselves but also impacts all aspects of analyzer operation. Good water purification design, especially providing recirculation through key purification technologies, is the key to effective and long-term bacterial control, which is the most challenging aspect of water purification.

The key requirements for water for clinical analyzers are:

  • Highly reliable, uninterrupted supply
  • Consistent high purity
  • Low running costs
  • Easy operation and minimal user intervention

 Standards for Clinical Grade Water

​The College of American Pathologists (CAP) accreditation is used in the USA and in laboratories in many other countries. The CAP recommendation is that, as a minimum, water in the laboratory should meet Clinical Laboratory Reagent Water (CLRW) as specified by CLSI (1).

CLSI (Clinical Laboratory Standards Institute)

Clinical Laboratory Reagent Water (CLRW)

​Resistivity @ 25°C (megohms-cm)​≥10
​Conductivity @ 25°C (micromhos/cm)​0.1
​Bacterial Growth (cfu/ml)​<10
​Organics​<500 ppb
​Particulate Matter​0.22 ​µm Filter*

*The specification is a process specification, and not measured by the end-user.

 Effects of Impurity in the Water

​The CLRW specification limits four key types of impurity in pure water: ions, particulates, organics, and bacteria and bacterial by-products. All will impact analyzer performance, either by direct interference with the chemistries of tests, or indirectly, by introducing errors in the measurements.

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